An epi-mono factorization system is an orthogonal factorization system in which the left class is the class of epimorphisms and the right class is the class of monomorphisms. Such a factorization system exists on any (elementary) topos, and indeed on any pretopos.
Note that any category which admits an epi-mono factorization system is necessarily balanced. This excludes many commonly occurring categories. More common are (strong epi, mono) and (epi, strong mono) factorization systems; the former exists in any regular category and the latter in any quasitopos, as well as in other categories such as Top.
(epi, mono) factorization system