is a $\kappa$-accessible functor (for $\kappa$ a regular cardinal) if $C$ and $D$ are both $\kappa$-accessible categories and $F$ preserves $\kappa$-filtered colimits. $F$ is an accessible functor if it is $\kappa$-accessible for some regular cardinal $\kappa$.

Properties

Raising the index of accessibility

If $\lambda\le\kappa$, then every $\kappa$-filtered colimit is also $\lambda$-filtered, and thus if $F$ preserves $\lambda$-filtered colimits then it also preserves $\kappa$-filtered ones. Therefore, if $F$ is $\lambda$-accessible and $C$ and $D$ are $\kappa$-accessible, then $F$ is $\kappa$-accessible. Two conditions under which this happens are:

$\lambda$ is sharply smaller than $\kappa$, i.e. $\lambda\lhd\kappa$.

In particular, for any accessible functor $F$ there are arbitrarily large cardinals $\kappa$ such that $F$ is $\kappa$-accessible, and if the domain and codomain of $F$ are locally presentable then $F$ is $\kappa$-accessible for all sufficiently large $\kappa$.

Preserving presentable objects

For any accessible functor $F$, there are arbitrarily large cardinals $\kappa$ such that $F$ is $\kappa$-accessible and preserves $\kappa$-presentable objects. Indeed, this can be achieved simultaneously for any set of accessible functors. See Adamek-Rosicky, Theorem 2.19.

The theory of accessible 1-categories is described in

Michael Makkai, Robert Paré, Accessible categories: The foundations of categorical model theory Contemporary Mathematics 104. American Mathematical Society, Rhode Island, 1989.