Quite generally, in a category with pullbacks (possibly homotopy pullbacks), given a morphism in its corresponding Čech nerve is the simplicial object in that in degree is given by the -fold fiber product of over with itself :
This mainly plays a role in the general context of the model structure on simplicial presheaves, where Čech covers are special cases of hypercovers.
The cohomology theory obtained by mapping out of Čech covers instead of general hypercovers is Čech cohomology.
A groupoid object in an (infinity,1)-category that is a Čech nerve exhibits as a delooping.
For the disjoint union of over a covering sieve with respect to a coverage, the objectwise connected components of the Čech nerve is the subfunctor corresponding to the sieve
This is described in more detail in the section “Interpretation in terms of higher descent and codescent” at sieve.