A locally small category is total if its Yoneda embedding has a left adjoint. If is total, is called cototal.
The definition above requires some set-theoretic assumption to ensure that the functor category exists, but it can be rephrased to say that the colimit of weighted by exists, for any . (This still involves quantification over large objects, however, so some foundational care is needed.) This version has an evident generalization to enriched categories.
Total categories satisfy a very satisfactory adjoint functor theorem: any colimit-preserving functor from a total category to a locally small category has a right adjoint.
Any category which is monadic over Set is total, as is any category admitting a topological functor to Set.