The homotopy category of an (infinity,1)-category is, roughly, the best 1-categorical approximation to . It has the same objects as , and its morphisms are equivalence classes of 1-morphisms in .
The details of the definition depend on the chosen model for -categories, as either
The homotopy category of a SSet-enriched category (equivalently of a Top-enriched category) is hom-wise the image under the functor
which sends each simplicial set to its set of connected components, i.e. to the set of path component?s:
Urs: something is missing here: the homotopy category of an -category is supposed to be enriched in , I think
Similar, but more complicated, definitions work for complete Segal spaces and Segal categories.
For quasi-categories, one can write down a definition similar to those of -enriched categories, but there is also the following direct construction:
the simplicial nerve functor Cat SSet has a left adjoint
and the homotopy category of a quasi-category (a simplicial set with extra properties) is its image under this functor.